Nodular fasciitis is a rare, non-malignant, rapidly growing, self-limited myofib robla stic/ fibrob lasti c soft tissue tumor. This lesion may cause differential diagnostic problems due to the lack of specific histopathological characteristics and, mainly, due to its histological appearance that resembles mesenchymal neoplasms. A 27-year-old female sought care due to a complaint of a firm and rapid, painless swelling in the tongue. After an excisional biopsy, the histopathological evaluation using hematoxylin-eosin stain showed skeletal muscle tissue with a well-delimited lesion with rich cellularity, consisting of spindle cells, relatively uniform nuclei over a fibrous stroma. The immunohistochemistry panel was used as a complementary diagnosis procedure and included INI1, S100, EMA (MUC1), DESMIN, AE1-AE3, AML, CD34, h-Caldesmon, and β-catenin. Based on clinical, histopathological, and immunohistochemical findings, the present case was diagnosed as nodular fasciitis. Comprehensive knowledge of this entity is essential for adequate therapy to avoid unnecessary aggressive treatment.
Cite this article as: Rizental Koubik G, Carolina Mehret Scorsin B, Claudino M, et al. Nodular fasciitis of the tongue. Essent Dent. 2022;1(3):109-112.